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Letrozole (1mg/capsule), 60 Capsules
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Laborergebnisse ansehen →Letrozole is a third-generation non-steroidal aromatase inhibitor that selectively targets CYP19A1 (aromatase), a cytochrome P450 enzyme responsible for catalyzing key steps in estrogen biosynthesis pathways.
By inhibiting aromatase activity, letrozole serves as a valuable research tool for investigating enzyme kinetics, substrate-enzyme interactions, steroidogenic pathway regulation, and feedback mechanisms associated with hormone biosynthesis networks.
Experimental studies have examined its effects on CYP19A1-mediated catalytic processes, transcriptional regulation of steroidogenic pathways, and interactions within endocrine signaling systems. Research applications include aromatase enzyme pharmacology, estrogen biosynthesis pathway investigation, steroidogenic enzyme research, and comparative studies of aromatase inhibitor pharmacology.
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3D Molecular Structure
Drag to rotate · scroll to zoom| Chemical Formula | C17H11N5 |
|---|---|
| Synonyms | Femara (trade name), CGS 20267, 4,4'-[(1H-1,2,4-triazol-1-yl)methylene]dibenzonitrile |
| Molar Mass | 285.31 g/mol |
| CAS Number | 112809-51-5 |
| PubChem CID | 3902 |
| Total Compound Content | 60 mg (1 mg per capsule) |
| Shelf Life | 36 months |
Results refer to the tested sample. Check the batch and date in the report.
How does letrozole's mechanism of aromatase inhibition differ from steroidal aromatase inhibitors?
Letrozole is a non-steroidal aromatase inhibitor that interacts reversibly with CYP19A1 through coordination of its triazole nitrogen with the enzyme's haem iron center. Steroidal aromatase inhibitors utilize a different structural framework and interact with the enzyme through distinct molecular mechanisms.
These differences make letrozole a valuable research tool for comparative investigations of aromatase inhibition, enzyme-ligand interactions, active-site binding characteristics, and CYP19A1 pharmacology.
What makes letrozole useful for aromatase pathway research?
Letrozole is a highly selective CYP19A1 inhibitor widely used to investigate aromatase-mediated catalytic processes, steroidogenic pathway regulation, enzyme kinetics, and substrate-enzyme interactions. Experimental studies employ letrozole to examine the role of aromatase within hormone biosynthesis networks, transcriptional regulation of steroidogenic pathways, and the molecular consequences of selective CYP19A1 inhibition.
What is the potency of letrozole in aromatase enzyme studies?
Letrozole demonstrates high affinity for CYP19A1 and exhibits potent inhibition of aromatase activity in experimental systems. Its well-characterized interaction with the aromatase active site has established it as a reference compound for studies of enzyme inhibition, concentration-response relationships, inhibitor selectivity, and comparative aromatase pharmacology.
These characteristics make letrozole a valuable tool for mechanistic investigations of CYP19A1 function and regulation.
