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Orforglipron 6mg / 90caps
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Voir la politique de livraison →Chaque lot est testé pour sa pureté, sa puissance et sa qualité.
Voir les résultats d’analyse →Orforglipron is a synthetic, non-peptidic GLP-1 receptor agonist studied in controlled research environments for its role in modulating glucagon-like peptide-1 signalling pathways. Research focuses on its activity in cAMP-dependent pathways, receptor activation dynamics, and peptide-regulated energy balance mechanisms.
Unlike traditional GLP-1 analogues, Orforglipron demonstrates oral bioactivity and high receptor selectivity, making it suitable for experimental models evaluating small molecule agonists in metabolic signalling systems.
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- For Laboratory Research Use Only
| Chemical Formula | C48H48F2N10O5 |
|---|---|
| Synonyms | LY3502970, OWL833, Foundayo (trade name) |
| Molar Mass | 883.0 g/mol |
| CAS Number | 2212020-52-3 |
| PubChem CID | 137319706 |
| Total Compound Content | 540 mg (6 mg per capsule) |
| Shelf Life | 36 months |
Every batch is independently lab tested for identity, purity and potency. View our lab testing program →
How does Orforglipron's binding mechanism differ from peptide GLP-1R agonists?
Peptide GLP-1R agonists interact primarily with the receptor's extracellular peptide-binding domain, whereas Orforglipron binds within the transmembrane region of GLP-1R through a distinct small-molecule binding site. This alternative binding mode stabilizes an active receptor conformation through a mechanism different from endogenous peptide ligands.
As a result, Orforglipron is a valuable research tool for investigating allosteric receptor activation, receptor conformational dynamics, and the differences between peptide-mediated and small-molecule-mediated GLP-1R signalling.
What advantages does Orforglipron provide for GLP-1R pharmacology research?
As an orally active small-molecule agonist, Orforglipron enables investigation of GLP-1R activation without the structural constraints associated with peptide ligands. This makes it useful for studies examining receptor binding-site architecture, signal-transduction mechanisms, receptor trafficking, ligand-specific signalling profiles, and the development of non-peptide class B GPCR agonists.
Its distinct binding mode also allows direct comparison of orthosteric versus non-orthosteric receptor activation mechanisms.
Why is Orforglipron important for studying GLP-1 receptor signalling?
Orforglipron provides a unique platform for exploring how different ligand classes activate the same receptor. Comparative studies can evaluate receptor activation kinetics, cAMP signalling, receptor internalisation, signalling bias, and conformational changes induced by small-molecule versus peptide agonists. These investigations contribute to a broader understanding of GLP-1R pharmacology and class B GPCR activation mechanisms.
