Utilisation : Ce produit est destiné uniquement à la recherche.
Toutes les informations sur les produits présentes sur ce site sont fournies à titre éducatif uniquement. Toute forme d’introduction dans le corps humain ou animal est strictement interdite par la loi. Ce produit doit être manipulé uniquement par des professionnels agréés et qualifiés. Il ne s’agit pas d’un médicament, d’un aliment ou d’un cosmétique et il ne doit pas être présenté, utilisé ou étiqueté comme tel.
Mirabegron 50mg
Pendant notre changement d’emballage, vous pouvez recevoir des produits avec l’ancienne ou la nouvelle étiquette. La formulation, la pureté et la qualité restent exactement les mêmes, selon nos standards.
- Carte de crédit
- Virement bancaire (SEPA instantané)
- Virement bancaire (ACH)
- Wise
- Revolut
- Zelle
- Remitly
- Western Union
- Chime
- Autres
-25% sur tout – jusqu’au 31 octobre
25% sur les prix habituels, en remplacement des autres soldes. Cumulable uniquement avec la remise crypto.
Expédition le jour même pour les commandes aux États-Unis passées avant 12 h EST.
Voir la politique de livraison →Chaque lot est testé pour sa pureté, sa puissance et sa qualité.
Voir les résultats d’analyse →Mirabegron is a selective β3-adrenoceptor (β3-AR) agonist investigated for its effects on β-adrenergic signaling pathways and receptor-mediated regulation of cellular activity. Experimental studies have examined its interactions with β3-AR-associated cAMP signaling, Gs-protein-coupled signal transduction mechanisms, and downstream regulatory pathways.
Its high selectivity for β3-adrenoceptors relative to β1- and β2-adrenoceptor subtypes makes it a valuable research tool for studies of receptor subtype pharmacology, adrenergic signaling networks, adipocyte-associated signaling mechanisms, thermogenic pathway regulation, and comparative β-adrenoceptor selectivity.
Research applications include β3-adrenoceptor pharmacology, G-protein-coupled receptor signaling, metabolic pathway investigation, and adrenergic receptor subtype characterization.
- High Purity – 99% Purity Guaranteed
- Independently Lab Tested
- Research Grade Quality
- For Laboratory Research Use Only
| Chemical Formula | C21H24N4O2S |
|---|---|
| Synonyms | YM-178, (R)-2-(2-Amino-1,3-thiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide |
| Molar Mass | 396.51 g/mol |
| CAS Number | 223673-61-8 |
| PubChem CID | 9865528 |
| Total Compound Content | 4,500 mg (50 mg per capsule) |
| Shelf Life | 36 months |
Results refer to the tested sample. Check the batch and date in the report.
What is the mechanistic basis for mirabegron's research interest in β3-adrenoceptor-mediated thermogenic signaling?
β3-adrenoceptor activation stimulates Gsα-mediated activation of adenylyl cyclase, increasing intracellular cAMP concentrations and downstream PKA signaling. This signaling cascade regulates UCP1-associated pathways, hormone-sensitive lipase (HSL) activation, PGC-1α-associated transcriptional programs, mitochondrial biogenesis mechanisms, and cellular energy expenditure pathways.
Mirabegron is frequently utilized as a selective β3-AR agonist in studies examining thermogenic signaling networks, receptor-mediated metabolic regulation, and adrenergic control of mitochondrial function.
How selective is mirabegron for β3-adrenoceptors relative to other β-adrenoceptor subtypes?
Mirabegron demonstrates substantially greater affinity for β3-adrenoceptors than for β1- or β2-adrenoceptors in receptor-binding and functional signaling assays. This selectivity allows experimental effects observed at appropriate concentrations to be primarily attributed to β3-AR activation.
In studies requiring rigorous receptor-subtype attribution, selective β1- and β2-adrenoceptor antagonists are often incorporated to distinguish β3-mediated signaling from potential off-target adrenergic activity.
Why is mirabegron used in β3-adrenoceptor pharmacology research?
Mirabegron is one of the most extensively characterized selective β3-adrenoceptor agonists available for experimental investigation. Its well-defined receptor pharmacology, documented activation of β3-AR-dependent signaling pathways, and favorable subtype selectivity make it a valuable research tool for studies of adrenergic receptor signaling, G-protein-coupled receptor pharmacology, cAMP-mediated signal transduction, thermogenic pathway regulation, mitochondrial signaling networks, and comparative β-adrenoceptor subtype characterization.
