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7,8-Dihydroxyflavone (10mg/capsule), 60 Capsules
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Voir les résultats d’analyse →7,8-Dihydroxyflavone (7,8-DHF) is a flavonoid compound studied for specific molecular pathway interactions in experimental models, with laboratory research indicating selective TrkB receptor modulation properties. Research interest centers on its proposed role as a tool compound for investigating TrkB receptor-mediated signalling distinct from peptide-based neurotrophic factor research.
Research applications include TrkB receptor pharmacology, comparative flavonoid receptor-modulator studies, and small-molecule neurotrophic signalling research.
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3D Molecular Structure
Drag to rotate · scroll to zoom| Chemical Formula | C15H10O4 |
|---|---|
| Synonyms | ADB6MA8ZV2, CHEMBL75267, Spectrum_001087, Spectrum2_000952, Spectrum3_000213 |
| CAS Number | 38183-03-8 |
| PubChem CID | 1880 |
| Total Compound Content | 600mg (10mg per 1 capsule) |
| Shelf Life | 36 months |
Every batch is independently lab tested for identity, purity and potency. View our lab testing program →
How does 7,8-Dihydroxyflavone's small-molecule structure compare to peptide-based TrkB pathway research tools?
As a small-molecule flavonoid, 7,8-Dihydroxyflavone offers researchers a chemically stable alternative to peptide-based neurotrophic factor research tools, which often face stability and blood-brain barrier penetration limitations in experimental design. Comparative research examining both compound classes at the TrkB receptor allows investigators to characterise whether observed signalling outcomes depend on receptor engagement mechanism or are specific to one structural class of research tool.
What receptor-binding assays are used to characterise 7,8-Dihydroxyflavone's TrkB selectivity profile?
Radioligand displacement assays and surface plasmon resonance are standard methods for quantifying 7,8-Dihydroxyflavone's binding affinity at the TrkB receptor, typically run alongside parallel assays at related receptor tyrosine kinases (such as TrkA or TrkC) to establish selectivity. These binding data are usually paired with cell-based functional assays measuring downstream receptor autophosphorylation to confirm that binding translates to receptor activation in the specific experimental model under study.
What downstream signalling endpoints are used to study 7,8-Dihydroxyflavone's TrkB pathway engagement?
Western blot analysis of TrkB receptor autophosphorylation and downstream kinase cascade activation (such as ERK or AKT pathway markers) in neuronal cell culture models is a standard approach for confirming functional TrkB pathway engagement following compound exposure. These molecular signalling readouts are often paired with cell-based functional assays relevant to the specific research question, allowing researchers to connect receptor-level engagement to downstream cellular outcomes.
