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Synephrine HCl – Powder, 20 grams
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Laborergebnisse ansehen →Synephrine HCl is the hydrochloride salt form of synephrine, a phenylethanolamine compound studied for its interactions with adrenergic receptor subtypes, with particular research interest in beta-3 adrenergic receptor selectivity relative to other adrenergic agonist compounds. The hydrochloride formulation improves aqueous solubility and stability for precision-based research applications.
Research applications include adrenergic receptor subtype selectivity studies, salt-form pharmacokinetic comparison, and comparative phenylethanolamine pharmacology.
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3D Molecular Structure
Drag to rotate · scroll to zoom| Chemical Formula | C9H14ClNO2 |
|---|---|
| Synonyms | 4-(1-Hydroxy-2-(methylamino)ethyl)phenol hydrochloride, Oxedrine hydrochloride, Synephrine (hydrochloride), MFCD00050566, Ocuton (TN) |
| Molar Mass | 203.66 g/mol |
| CAS Number | 5985-28-4 |
| PubChem CID | 42609626 |
| Total Compound Content | 20 grams |
| Shelf Life | 36 months |
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How does the hydrochloride salt form of synephrine differ from the free base in solubility and research handling?
The hydrochloride salt confers substantially improved aqueous solubility and dissolution rate compared to the free-base form, making it more practical for preparing reproducible stock solutions for in vitro receptor-binding assays and aqueous-vehicle rodent dosing protocols. Researchers should account for the additional mass contribution of the chloride counter-ion when converting between mass-based and molar-based dosing calculations across studies using different salt forms.
What metabolic pathways are studied for synephrine HCl clearance in pharmacokinetic research?
Synephrine HCl is studied as undergoing hepatic metabolism primarily via monoamine oxidase (MAO)-mediated oxidative deamination and phase II sulfation conjugation, with the resulting metabolites cleared predominantly through renal excretion. Pharmacokinetic studies characterising these pathways typically use MAO inhibitor co-administration to isolate the contribution of oxidative versus conjugative metabolism to overall clearance, informing dose-timing and metabolite-monitoring decisions in longer-duration in vivo protocols.
Why might researchers select the hydrochloride salt powder format over the pre-made solution format for synephrine studies?
Powder format allows researchers to prepare custom-concentration stock solutions tailored to their specific solvent system and required final concentration range, offering greater flexibility for dose-response curve generation than a single fixed-concentration solution product. This is particularly relevant for in vitro receptor-binding assays requiring a wide concentration range to establish full dose-response curves, or for studies requiring a non-aqueous solvent system not compatible with a pre-formulated aqueous solution.
