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Amentoflavone (20% extract) – Powder, 2.5 grams
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Vedi i risultati di laboratorio →Amentoflavone is a biflavonoid compound composed of two linked apigenin flavonoid units, classified structurally as 3',8''-biapigenin. Research interest centers on its receptor-binding profile and enzymatic pathway interactions characterised in controlled in vitro studies, distinguishing it from monomeric flavonoid compounds due to its dimeric structure.
Research applications include biflavonoid structure-activity studies, enzymatic pathway research, and comparative flavonoid dimerization chemistry investigation.
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3D Molecular Structure
Drag to rotate · scroll to zoom| Chemical Formula | C30H18O10 |
|---|---|
| Synonyms | Didemethyl-ginkgetin, 3',8''-Biapigenin, Amenthoflavone |
| Molar Mass | 538.5 g/mol |
| CAS Number | 1617-53-4 |
| PubChem CID | 5281600 |
| Total Compound Content | 20% extract (2.5 grams) |
| Shelf Life | 36 months |
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How does amentoflavone's biflavonoid structure distinguish it from monomeric flavonoid compounds in research?
Amentoflavone consists of two apigenin flavonoid units joined at a specific linkage position (3',8''-biapigenin), creating a larger, more rigid molecular scaffold than monomeric flavonoids. This dimeric structure is studied for how it influences receptor-binding geometry, membrane permeability, and target selectivity compared to the corresponding monomeric apigenin unit, providing a model system for biflavonoid structure-activity relationship research more broadly.
What is the significance of using a standardized 20% extract format in amentoflavone research protocols?
A standardised extract percentage (20% amentoflavone content by weight) ensures researchers can calculate precise active-compound dosing from a consistent starting material, which is important for reproducibility when the extract is derived from plant source material that can have variable natural amentoflavone concentration. Researchers should account for this 20% standardisation when converting total extract mass to active amentoflavone mass for molar concentration calculations in experimental protocols.
What enzymatic assay approaches are used to characterize amentoflavone's molecular target interactions?
Standard approaches include enzyme inhibition assays measuring amentoflavone's effect on relevant enzymatic activity (using purified enzyme preparations and substrate-conversion readouts), alongside receptor or protein-binding assays such as fluorescence polarization or surface plasmon resonance to directly characterise binding affinity. Comparative assays run alongside the monomeric apigenin unit are often used to determine whether the biflavonoid linkage enhances, reduces, or otherwise alters target engagement relative to the parent monomer.
