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Mirabegron 50mg
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Ver resultados de laboratorio →Mirabegron is a selective β3-adrenoceptor (β3-AR) agonist investigated for its effects on β-adrenergic signaling pathways and receptor-mediated regulation of cellular activity. Experimental studies have examined its interactions with β3-AR-associated cAMP signaling, Gs-protein-coupled signal transduction mechanisms, and downstream regulatory pathways.
Its high selectivity for β3-adrenoceptors relative to β1- and β2-adrenoceptor subtypes makes it a valuable research tool for studies of receptor subtype pharmacology, adrenergic signaling networks, adipocyte-associated signaling mechanisms, thermogenic pathway regulation, and comparative β-adrenoceptor selectivity.
Research applications include β3-adrenoceptor pharmacology, G-protein-coupled receptor signaling, metabolic pathway investigation, and adrenergic receptor subtype characterization.
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- For Laboratory Research Use Only
| Chemical Formula | C21H24N4O2S |
|---|---|
| Synonyms | YM-178, (R)-2-(2-Amino-1,3-thiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide |
| Molar Mass | 396.51 g/mol |
| CAS Number | 223673-61-8 |
| PubChem CID | 9865528 |
| Total Compound Content | 4,500 mg (50 mg per capsule) |
| Shelf Life | 36 months |
Results refer to the tested sample. Check the batch and date in the report.
What is the mechanistic basis for mirabegron's research interest in β3-adrenoceptor-mediated thermogenic signaling?
β3-adrenoceptor activation stimulates Gsα-mediated activation of adenylyl cyclase, increasing intracellular cAMP concentrations and downstream PKA signaling. This signaling cascade regulates UCP1-associated pathways, hormone-sensitive lipase (HSL) activation, PGC-1α-associated transcriptional programs, mitochondrial biogenesis mechanisms, and cellular energy expenditure pathways.
Mirabegron is frequently utilized as a selective β3-AR agonist in studies examining thermogenic signaling networks, receptor-mediated metabolic regulation, and adrenergic control of mitochondrial function.
How selective is mirabegron for β3-adrenoceptors relative to other β-adrenoceptor subtypes?
Mirabegron demonstrates substantially greater affinity for β3-adrenoceptors than for β1- or β2-adrenoceptors in receptor-binding and functional signaling assays. This selectivity allows experimental effects observed at appropriate concentrations to be primarily attributed to β3-AR activation.
In studies requiring rigorous receptor-subtype attribution, selective β1- and β2-adrenoceptor antagonists are often incorporated to distinguish β3-mediated signaling from potential off-target adrenergic activity.
Why is mirabegron used in β3-adrenoceptor pharmacology research?
Mirabegron is one of the most extensively characterized selective β3-adrenoceptor agonists available for experimental investigation. Its well-defined receptor pharmacology, documented activation of β3-AR-dependent signaling pathways, and favorable subtype selectivity make it a valuable research tool for studies of adrenergic receptor signaling, G-protein-coupled receptor pharmacology, cAMP-mediated signal transduction, thermogenic pathway regulation, mitochondrial signaling networks, and comparative β-adrenoceptor subtype characterization.
